BioSurgery Advancing Surgery, Enhancing Life

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Synthetic sealing for areas of potential leakage.

COSEAL is a biocompatible polyethylene glycol polymer that rapidly cross-links with proteins in tissue to immediately adhere to the area of application.  This is ideal during vascular reconstruction when you want to seal potential areas of leakage.

COSEAL [Surgical Sealant] Indications
COSEAL is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.1

  • Polymerization occurs in approximately 5 seconds2
  • Demonstrated to seal leak pressures of [660 +/- 150] mmHg (in vitro burst test for closure of puncture defects 0.6-0.9mm in diameter in porcine carotid artery, n=4)3
  • Sealing and hemostasis unaffected by patient's coagulation status2
  • Fully synthetic, not containing any animal or human proteins or gluteraldehyde
  • Successfully adheres to synthetic materials1
  • EasySpray application system allows coverage of broad surface areas with maximum product utilization
  • Does not produce an adverse tissue response and resorbs fully in 4 weeks2,4
  • Flexible hydrogel that won't restrict movement of surrounding physiology

Easy to use- Enhanced Spray Application1,5

  • Two distinct polyethylene glycol polymers chemically bond together to form COSEAL sealant
  • Seal tissue surfaces, suture lines and synthetic grafts
  • Ideal for sealing around vascular reconstructions to achieve adjunctive hemostasis
  • Rapid preparation and sealing times may reduce time in surgery
  • Easy to control delivery system helps facilitate effective application
     

Order Information

Order # Description
934070 COSEAL [Surgical Sealant] 2mL
934071 COSEAL [Surgical Sealant] 4 mL
934072 COSEAL [Surgical Sealant] 8 mL
934033 COSEAL Replacement Applicator
934034 COSEAL Extended Applicator
934500 Spray Accessory Kit
0600012 EasySpray Kit
0600021 COSEAL Sprayset

COSEAL [Surgical Sealant] is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.

COSEAL Prescribing Information

Important COSEAL Safety Information

References

  1. COSEAL [Surgical Sealant] Instructions for Use, 03/2006.
  2. Hill A, Estridge TD Maroney M, Monnet E, Egbert B, Cruise G & Coker GT. Treatment of suture line bleeding with a novel synthetic surgical sealant in acanine iliac PTFE graft model. January (2001) : 308-312.
  3. Wallace DG, Cruise GM, Rhee WM, Schroeder JA, Prior JJ, Ju J, Maroney M, Duronio J, Ngo MH, Estridge T, & Cocker GC. A tissue sealant based onreactive multifunctional polyetheylene glycol. May (2001) :545-555.
  4. Glickman M, Gheissari A, Money S, Martin J, & Ballard JL. A polymeric sealant inhibits anastomotic suture hold bleeding more rapidly than Gelfoam/Thrombin. Arch Surg. Vol 137: March (2002) :326-331.
  5. EasySpray Instructions For Use, 62080CEH07

COSEAL is a registered trademark of Angiodevice International GmbH, used under license.